SIGLEC
Sign in to saveAlso known as Sialic acid-binding Ig-like lectin, sialoadhesin, sialic acid binding immunoglobulin-like lectins, sialic acid binding immunoglobulin-like lectin
Siglecs (Sialic acid-binding immunoglobulin-type lectins) are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. There are 14 different mammalian Siglecs, providing an array of different functions based on cell surface receptor-ligand interactions.
In the Vinony graph
Within Vinony's link graph, SIGLEC is referenced by 52 other articles, and connects out to CD33 molecule, CD22 molecule and MAG.
Vinony files it under Protein pages needing a picture and Siglec.
Its subject is documented across 6 Wikipedia language editions.
Research
6,552 papers- Siglec Ligands.Cells · 2021
- Targeting CD24/Siglec-10 signal pathway for cancer immunotherapy: recent advances and future directions.Cancer immunology, immunotherapy : CII · 2024
- Siglec-mediated regulation of immune cell function in disease.Nature reviews. Immunology · 2014
- Gangliosides as Siglec ligands.Glycoconjugate journal · 2023
- MicroRNA:Siglec crosstalk in cancer progression.Current opinion in chemical biology · 2024
via PubMed
Wikidata facts
Show 2 more facts
- Commons category
- Siglecs
via Wikidata · CC0
~16 min read
Encyclopedic overview
12 sectionsContents
- History
- Structure
- Ligand binding
- Function
- Signalling
- Phagocytosis and adhesion
- Knock-out studies
- Human/Primate Siglecs
- Mimetics
- Synthesis
- References
- External links
Siglecs (Sialic acid-binding immunoglobulin-type lectins) are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. There are 14 different mammalian Siglecs, providing an array of different functions based on cell surface receptor-ligand interactions.
==History==
Excerpted from Wikipedia’s “SIGLEC” article, available under the CC BY-SA 4.0 licence.