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GeneQ18045148· pop 7· linked from 5 articles

SIGIRR

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Also known as TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, IL-1R8, single Ig and TIR domain containing

Single Ig IL-1-related receptor (SIGIRR), also called Toll/Interleukin-1 receptor 8 (TIR8) or Interleukin-1 receptor 8 (IL-1R8), is transmembrane protein encoded by gene SIGIRR, which modulate inflammation, immune response, and tumorigenesis of colonic epithelial cells.

Gene data

SIGIRR
Name
single Ig and TIR domain containing
Type
protein-coding
Position
405,711–417,473 (−)
Aliases
IL-1R8, TIR8
Ensembl
ENSG00000185187
RefSeq RNA
NM_001135053.2, NM_001135054.2, NM_021805.3, XM_005253045.1, XM_005253046.2
RefSeq protein
NP_001128525.1, NP_001128526.1, NP_068577.2, XP_005253102.1, XP_005253103.1

Predicted to enable NAD+ nucleosidase activity. Involved in negative regulation of DNA-binding transcription factor activity. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Molecular function

protein binding

Pathways

Cytokine Signaling in Immune systemToll Like Receptor 4 (TLR4) CascadeMyD88:MAL(TIRAP) cascade initiated on plasma membraneToll Like Receptor TLR1:TLR2 CascadeToll Like Receptor TLR6:TLR2 CascadeInnate Immune SystemImmune SystemToll-like Receptor CascadesToll Like Receptor 2 (TLR2) CascadeInterleukin-1 family signaling

via MyGene.info

Gene · Ensembl

single Ig and TIR domain containing

Symbol
SIGIRR
Biotype
Protein coding
Organism
Homo sapiens
Location
11:405,711-417,473
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~6 min read

Encyclopedic overview

7 sections
Contents
  • Gene
  • Structure
  • Expression
  • Function
  • SIGIRR as a coreceptor of IL-1R5 for IL-37 binding
  • References
  • Further reading

Single Ig IL-1-related receptor (SIGIRR), also called Toll/Interleukin-1 receptor 8 (TIR8) or Interleukin-1 receptor 8 (IL-1R8), is transmembrane protein encoded by gene SIGIRR, which modulate inflammation, immune response, and tumorigenesis of colonic epithelial cells.

== Gene == Human gene SIGIRR is localized on chromosome 11. It is composed of 10 exons spanning about 11,700 base pairs. In mice, this gene is on chromosome 7, where it is composed of 9 exons spanning about 9,400 base pairs.

Excerpted from Wikipedia’s “SIGIRR” article, available under the CC BY-SA 4.0 licence.

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