IL18

Name

interleukin 18

Type

protein-coding

Position

112,143,251–112,164,106 (−)

Aliases

IGIF, IL-18, IL-1g, IL1F4

Ensembl

ENSG00000150782

RefSeq RNA

NM_001243211.2, NM_001386420.1, NM_001440428.1, NM_001440429.1, NM_001562.4

RefSeq protein

NP_001230140.1, NP_001373349.1, NP_001427357.1, NP_001427358.1, NP_001553.1

The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2020].

via MyGene.info

Gene · Ensembl

interleukin 18

Symbol

IL18

Biotype

Protein coding

Organism

Homo sapiens

Location

11:112,142,701-112,164,391

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

IL18 Solution Structure.rsh.png

via Wikidata · CC0