IL17RD

Also known as HH18, IL-17RD, IL17RLM, SEF, interleukin 17 receptor D

Interleukin 17 receptor D (also known as Sef) is a protein that in humans is encoded by the IL17RD gene.

Gene data

IL17RD

Name: interleukin 17 receptor D
Type: protein-coding
Position: 57,089,982–57,170,306 (−)
Aliases: HH18, IL-17RD, IL17RLM, SEF
Ensembl: ENSG00000144730
RefSeq RNA: NM_001318864.2, NM_017563.5, XM_005265238.5, XM_011533849.2, XM_047448369.1
RefSeq protein: NP_001305793.1, NP_060033.3, XP_005265295.1, XP_011532151.2, XP_047304325.1

This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016].

Gene Ontology

Biological process

negative regulation of epithelial to mesenchymal transition

Article

9 sections

Contents

Identification
Structure
IL-17RD in development
IL-17RD in inflammation
IL-17 signaling
TLR signaling
TNF signaling
References
Further reading

Interleukin 17 receptor D (also known as Sef) is a protein that in humans is encoded by the IL17RD gene.

This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. Alternate splicing generates multiple transcript variants encoding distinct isoforms. IL-17RD has been described to limit fibroblast growth factor receptor (FGFR) signaling and to be a part of the IL-17 receptor signaling complex.