C-C motif chemokine receptor 5
Also known as chemokine (C-C motif) receptor 5, chemokine receptor CCR5, chemokine recptor CCR5 Delta32, chemr13, C-C chemokine receptor type 5, CCR5, C-C motif chemokine receptor 5 A159A, HIV-1 fusion coreceptor
C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines.
Clinical Trials
7 registered- PHASE1COMPLETEDPhase 1 Dose Escalation Study of Autologous T-cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases in HIV-Infected PatientsSangamo Therapeutics · NCT01044654
- PHASE1/PHASE2COMPLETEDRepeat Doses of SB-728mR-T After Cyclophosphamide Conditioning in HIV-Infected Subjects on HAARTSangamo Therapeutics · NCT02225665
- PHASE1/PHASE2COMPLETEDStudy of Autologous T-cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases in HIV-Infected SubjectsSangamo Therapeutics · NCT01252641
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~12 min read
Article
12 sectionsContents
- Tissue distribution
- Structure
- Function
- Clinical significance
- HIV
- Cancer
- Stroke
- CCR5-Δ32
- See also
- References
- Further reading
- External links
C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines.
In humans, the CCR5 gene that encodes the CCR5 protein is located on the short (p) arm at position 21 on chromosome 3. Certain populations have inherited the Delta 32 mutation, resulting in the genetic deletion of a portion of the CCR5 gene. Homozygous carriers of this mutation are resistant to infection by macrophage-tropic (M-tropic) strains of HIV-1.