CCR9
Sign in to saveAlso known as CC-CKR-9, CDw199, GPR-9-6, GPR28, C-C motif chemokine receptor 9
C-C chemokine receptor type 9 is a protein that in humans is encoded by the CCR9 gene. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described.
In the Vinony graph
Within Vinony's link graph, CCR9 is referenced by 502 other articles, and connects out to PubMed, chemokine and Ensembl genome database project.
It sits within the topics Chemokine receptors, Clusters of differentiation and Genes on human chromosome 3.
Its subject is documented across 5 Wikipedia language editions.
Gene data
CCR9- Name
- C-C motif chemokine receptor 9
- Type
- protein-coding
- Position
- 45,884,425–45,904,311 (+)
- Aliases
- CC-CKR-9, CDw199, GPR-9-6, GPR28
- Ensembl
- ENSG00000173585
- RefSeq RNA
- NM_001256369.2, NM_001386447.1, NM_001386448.1, NM_006641.4, NM_031200.3
- RefSeq protein
- NP_001243298.1, NP_001373376.1, NP_001373377.1, NP_006632.2, NP_112477.1
The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the beta chemokine receptor family. Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammation conditions. This gene is differentially expressed in T lymphocytes of the small intestine and colon, and its interaction with chemokine 25 contributes to intestinal intra-epithelial lymphocyte homing to the small intestine. This suggests a role for this gene in directing immune responses to different segments of the gastrointestinal tract. This gene and its exclusive ligand, chemokine 25, are overexpressed in a variety of malignant tumors and are closely associated with tumor proliferation, apoptosis, invasion, migration and drug resistance. This gene maps to the chemokine receptor gene cluster. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
C-C motif chemokine receptor 9
- Symbol
- CCR9
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:45,884,425-45,904,311
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 22546
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10803
- genomic end
- 45903174
- genomic start
- 45886509
- chromosome
- human chromosome 3
- cytogenetic location
- 3p21.31
- expressed in
- monocyte
Sources (3)
via Wikidata · CC0
~5 min read
Encyclopedic overview
8 sectionsContents
- Function
- Clinical significance
- Inflammatory Bowel Disease (IBD)
- Myocardial Infarction (MI)
- Cancer
- References
- Further reading
- External links
C-C chemokine receptor type 9 is a protein that in humans is encoded by the CCR9 gene. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described.
CCR9 has also recently been designated CDw199 (cluster of differentiation w199).
Excerpted from Wikipedia’s “CCR9” article, available under the CC BY-SA 4.0 licence.