ADGRL1

Also known as CIRL1, CL1, LEC2, LPHN1, adhesion G protein-coupled receptor L1

protein-coding gene in the species Homo sapiens

Gene data

ADGRL1

Name: adhesion G protein-coupled receptor L1
Type: protein-coding
Aliases: CIRL1, CL1, DEDBANP, LEC2, LPHN1

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008].

via MyGene.info