CELSR2
Sign in to saveAlso known as CDHF10, EGFL2, Flamingo1, MEGF3, ADGRC2, cadherin EGF LAG seven-pass G-type receptor 2
Cadherin EGF LAG seven-pass G-type receptor 2 is a protein that in humans is encoded by the CELSR2 gene.
Gene data
CELSR2- Name
- cadherin EGF LAG seven-pass G-type receptor 2
- Type
- protein-coding
- Aliases
- ADGRC2, CDHF10, EGFL2, Flamingo1, MEGF3
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
cadherin EGF LAG seven-pass G-type receptor 2
- Symbol
- CELSR2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:109,249,539-109,275,751
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 1078
- exact match
- identifiers.org/ncbigene/1952
- genomic end
- 109275751
- genomic start
- 109249539
- cytogenetic location
- 1p13.3
via Wikidata · CC0
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Article
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- See also
- References
- Further reading
- External links
Cadherin EGF LAG seven-pass G-type receptor 2 is a protein that in humans is encoded by the CELSR2 gene.
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.