AIM2

Also known as PYHIN4, absent in melanoma 2

Interferon-inducible protein AIM2 also known as absent in melanoma 2 or simply AIM2 is a protein that in humans is encoded by the AIM2 gene.

Gene data

AIM2

Name: absent in melanoma 2
Type: protein-coding
Position: 159,056,129–159,188,222 (−)
Aliases: PYHIN4
Ensembl: ENSG00000163568
RefSeq RNA: NM_001348247.2, NM_004833.3, XM_047434808.1, XM_047434809.1, XM_047434811.1
RefSeq protein: NP_001335176.1, NP_004824.1, XP_047290764.1, XP_047290765.1, XP_047290767.1

AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008].

Pathways

NOD-like receptor signaling pathway - Homo sapiens (human)Cytosolic DNA-sensing pathway - Homo sapiens (human)Innate Immune System Innate Immune System Immune System Immune System Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Cytosolic sensors of pathogen-associated DNA Inflammasomes

via MyGene.info

Gene · Ensembl

absent in melanoma 2

Symbol: AIM2
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:159,056,129-159,188,222
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 83226
exact match: identifiers.org/ncbigene/9447
genomic end: 159187843
genomic start: 159061599
cytogenetic location: 1q23.1|1q23.1-q23.2

Sources (6)

via Wikidata · CC0

~8 min read

Article

13 sections

Contents

Structure
Function
Regulation
Clinical relevance
Infection
Bacteria
Viruses
Other pathogens
Cancer
Inflammatory, autoimmune, and other pathological conditions
References
Further reading
External links

Interferon-inducible protein AIM2 also known as absent in melanoma 2 or simply AIM2 is a protein that in humans is encoded by the AIM2 gene.

AIM2 is a cytoplasmic sensor found in hematopoietic cells that recognizes the presence of double-stranded DNA (dsDNA) of microbial or host cellular origin. AIM2-like receptor (ALR) family was founded on AIM2 and now consists of four members in human genome. Activated AIM2 recruits apoptosis-associated speck-like protein containing a CARD (ASC), resulting in caspase-1 binding, and forming of AIM2 inflammasome. This signaling contributes to the defense against bacterial and viral DNA. The AIM2 inflammasome can also be an integral component of the AIM2-PANoptosome to drive PANoptosis.