AIM2

Also known as PYHIN4, absent in melanoma 2

Interferon-inducible protein AIM2 also known as absent in melanoma 2 or simply AIM2 is a protein that in humans is encoded by the AIM2 gene.

Gene data

AIM2

Name: absent in melanoma 2
Type: protein-coding
Position: 159,056,129–159,188,222 (−)
Aliases: PYHIN4
Ensembl: ENSG00000163568
RefSeq RNA: NM_001348247.2, NM_004833.3, XM_047434808.1, XM_047434809.1, XM_047434811.1
RefSeq protein: NP_001335176.1, NP_004824.1, XP_047290764.1, XP_047290765.1, XP_047290767.1

AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

activation of innate immune response activation of innate immune response activation of innate immune response

Article

13 sections

Contents

Structure
Function
Regulation
Clinical relevance
Infection
Bacteria
Viruses
Other pathogens
Cancer
Inflammatory, autoimmune, and other pathological conditions
References
Further reading
External links

Interferon-inducible protein AIM2 also known as absent in melanoma 2 or simply AIM2 is a protein that in humans is encoded by the AIM2 gene.

AIM2 is a cytoplasmic sensor found in hematopoietic cells that recognizes the presence of double-stranded DNA (dsDNA) of microbial or host cellular origin. AIM2-like receptor (ALR) family was founded on AIM2 and now consists of four members in human genome. Activated AIM2 recruits apoptosis-associated speck-like protein containing a CARD (ASC), resulting in caspase-1 binding, and forming of AIM2 inflammasome. This signaling contributes to the defense against bacterial and viral DNA. The AIM2 inflammasome can also be an integral component of the AIM2-PANoptosome to drive PANoptosis.