CKAP2

Also known as LB1, TMAP, se20-10, cytoskeleton associated protein 2

Cytoskeleton-associated protein 2 is a protein that in humans is encoded by the CKAP2 gene.

Gene data

CKAP2

Name: cytoskeleton associated protein 2
Type: protein-coding
Position: 52,455,429–52,476,630 (+)
Aliases: LB1, TMAP, se20-10
Ensembl: ENSG00000136108
RefSeq RNA: NM_001098525.3, NM_001286686.2, NM_001286687.2, NM_018204.5, XM_005266344.5
RefSeq protein: NP_001091995.1, NP_001273615.1, NP_001273616.1, NP_060674.3, XP_005266401.1

This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. [provided by RefSeq, Nov 2013].

Gene Ontology

Biological process

mitotic cytokinesis negative regulation of microtubule depolymerization

Article

3 sections

Contents

References
External links
Further reading

Cytoskeleton-associated protein 2 is a protein that in humans is encoded by the CKAP2 gene.

Human CKAP2 gene, the cDNA of which is known as LB1, is a cytoskeleton-associated protein involved in mitotic progression. Its high transcriptional activity has been observed in the testes, thymus, and diffuse B-cell lymphomas. The gene codes for a protein of 683 residues, which lacks a homology to known amino acid sequences. On evidence of immunofluorescence analysis, the CKAP2 product is a cytoplasmic protein associated with cytoskeletal fibrils. The CKAP2 gene is in chromosome 13q14. Rearrangements of this region result in various tumors. Thus deletions have been detected in multiple myeloma, prostate cancer, head-and-neck squamous-cell carcinoma, B-cell prolymphocytic leukemia, non-Hodgkin lymphoma, and in more than half cases of B-cell chronic lymphocytic leukemia.