CYTH2

Name

cytohesin 2

Type

protein-coding

Position

48,469,208–48,482,314 (+)

Aliases

ARNO, CTS18, CTS18.1, PSCD2, PSCD2L, SEC7L, Sec7p-L, Sec7p-like, cytohesin-2

Ensembl

ENSG00000105443

RefSeq RNA

NM_004228.7, NM_017457.6, XM_006723472.3, XM_047439682.1, XM_047439683.1

RefSeq protein

NP_004219.3, NP_059431.1, XP_006723535.1, XP_047295638.1, XP_047295639.1

The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].

via MyGene.info

Gene · Ensembl

cytohesin 2

Symbol

CYTH2

Biotype

Protein coding

Organism

Homo sapiens

Location

19:48,469,203-48,482,314

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein PSCD2 PDB 1pbv.png

via Wikidata · CC0