Cytoglobin
Sign in to saveAlso known as histoglobin, CYGB, HGb, stellate cell activation-associated protein
Cytoglobin is the protein product of CYGB, a human and mammalian gene.
Protein · UniProt
Cytoglobin
- Gene
- CYGB
- Organism
- Homo sapiens (Human)
- Length
- 190 aa
- Molecular mass
- 21,405 Da
- Evidence
- 1: Evidence at protein level
Probable multifunctional globin with a hexacoordinated heme iron required for the catalysis of various reactions depending on redox condition of the cell as well as oxygen availability (PubMed:11893755, PubMed:12359339, PubMed:15165856, PubMed:19147491, PubMed:20511233, PubMed:28393874, PubMed:28671819, PubMed:29128400, PubMed:33576020, PubMed:34930834). Has a nitric oxide dioxygenase (NOD) activity and is most probably involved in cell-mediated and oxygen-dependent nitric oxide consumption (PubMed:19147491, PubMed:20511233, PubMed:28393874, PubMed:28671819). By scavenging this second messe…
Swiss-Prot (reviewed) · via UniProt
Research
446 papers- Insights into the function of cytoglobin.Biochemical Society transactions · 2023
- Emerging perspectives on cytoglobin, beyond NO dioxygenase and peroxidase.Redox biology · 2020
- Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis.Clinical and molecular hepatology · 2020
- Cytoglobin scavenges intracellular hydrogen peroxide and regulates redox signals in the vasculature.Redox biology · 2025
- Cytoglobin has potent superoxide dismutase function.Proceedings of the National Academy of Sciences of the United States of America · 2021
via PubMed
Wikidata facts
Show 1 more fact
- exact match
- purl.uniprot.org/uniprot/Q8WWM9
Sources (3)
via Wikidata · CC0
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Article
6 sectionsContents
- Function
- Structure
- Applications
- References
- Further reading
- External links
Cytoglobin is the protein product of CYGB, a human and mammalian gene.
Cytoglobin is a globin molecule ubiquitously expressed in all tissues and most notably utilized in marine mammals. It was discovered in 2001 in hepatic stellate cells during liver fibrosis. Thus, it was originally called "stellate cell activated protein" or STAP. It received its current name in 2002. It is thought to help in the distribution and storage of oxygen as well as protect against hypoxia by scavenging reactive oxygen species . The predicted function of cytoglobin is the facilitation of oxygen among tissues that don't express myoglobin.