Arrestin beta 1

Protein · UniProt

Beta-arrestin-1

Gene

ARRB1

Organism

Homo sapiens (Human)

Length

418 aa

Molecular mass

47,066 Da

Evidence

1: Evidence at protein level

Functions in regulating agonist-mediated G protein-coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes (PubMed:37209686, PubMed:38175886, PubMed:40384633). During homologous desensitization, beta-arrestins bind to the GPCR-phosphorylated receptor and sterically preclude its coupling to the cognate G protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associa…

• AMPK Attenuation of β-Adrenergic Receptor-Induced Cardiac Injury via Phosphorylation of β-Arrestin-1-ser330.Circulation research · 2024
• β-Arrestin 1 in Thyrotropin Receptor Signaling in Bone: Studies in Osteoblast-Like Cells.Frontiers in endocrinology · 2020
• GLP-1 and GIP receptors signal through distinct β-arrestin 2-dependent pathways to regulate pancreatic β cell function.Cell reports · 2023
• Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics.Cell · 2022
• The extracellular matrix protein type I collagen and fibronectin are regulated by β-arrestin-1/endothelin axis in human ovarian fibroblasts.Journal of experimental & clinical cancer research : CR · 2025

via PubMed

• PHASE4COMPLETED
  Beta-arrestins and Response to Venlafaxine in Major Depressive Disorder (MDD) (DEPARRESTCLIN)Institut National de la Santé Et de la Recherche Médicale, France · NCT02051413

via ClinicalTrials.gov

Wikidata facts

Instance of

protein

via Wikidata · CC0