arrestin
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Arrestins (abbreviated Arr) are a small family of proteins important for regulating signal transduction at G protein-coupled receptors. Arrestins were first discovered in the late '80s as a part of a conserved two-step mechanism for regulating the activity of G protein-coupled receptors (GPCRs) in the visual rhodopsin system by Hermann Kühn, Scott Hall, and Ursula Wilden and in the β-adrenergic system by Martin J. Lohse and co-workers.
Research
7,918 papers- Receptor-Arrestin Interactions: The GPCR Perspective.Biomolecules · 2021
- Arrestin-dependent internalization of rhodopsin-like G protein-coupled receptors.Biological chemistry · 2022
- Snapshot of the cannabinoid receptor 1-arrestin complex unravels the biased signaling mechanism.Cell · 2023
- Arrestin mutations: Some cause diseases, others promise cure.Progress in molecular biology and translational science · 2019
- Arrestin recognizes GPCRs independently of the receptor state.Proceedings of the National Academy of Sciences of the United States of America · 2025
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Wikidata facts
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Article
9 sectionsContents
- Function
- Subtypes
- Tissue distribution
- Mechanism
- Structure
- Application
- Binding to rhodopsin
- References
- External links
Arrestins (abbreviated Arr) are a small family of proteins important for regulating signal transduction at G protein-coupled receptors. Arrestins were first discovered in the late '80s as a part of a conserved two-step mechanism for regulating the activity of G protein-coupled receptors (GPCRs) in the visual rhodopsin system by Hermann Kühn, Scott Hall, and Ursula Wilden and in the β-adrenergic system by Martin J. Lohse and co-workers.
== Function ==
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