English

English Deutsch Español Français Italiano Nederlands Português Svenska العربية 中文日本語

GeneQ18028548· pop 8· linked from 620 articles

LHCGR

Sign in to save

Also known as HHG, LCGR, LGR2, LH/CG-R, LH/CGR, LHR, LHRHR, LSH-R

protein-coding gene in the species Homo sapiens

Gene data

LHCGR

Name: luteinizing hormone/choriogonadotropin receptor
Type: protein-coding
Position: 48,686,774–48,755,730 (−)
Aliases: HHG, LCGR, LGR2, LH/CG-R, LH/CGR, LHR, LHRHR, LSH-R, ULG5
Ensembl: ENSG00000138039
RefSeq RNA: NM_000233.4, NM_001445839.1, NM_001445840.1, NM_001445841.1, XM_005264309.4
RefSeq protein: NP_000224.2, NP_001432768.1, NP_001432769.1, NP_001432770.1, XP_005264366.1

This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

ovarian follicle development G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway

Molecular function

G protein-coupled receptor activity luteinizing hormone receptor activity luteinizing hormone receptor activity luteinizing hormone receptor activity G protein-coupled peptide receptor activity protein-hormone receptor activity choriogonadotropin hormone receptor activity choriogonadotropin hormone receptor activity

Cellular component

endosome plasma membrane plasma membrane plasma membrane plasma membrane plasma membrane membrane

Pathways

Calcium signaling pathway - Homo sapiens (human)cAMP signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Ovarian steroidogenesis - Homo sapiens (human)Prolactin signaling pathway - Homo sapiens (human)Signal Transduction Signaling by GPCR Class A/1 (Rhodopsin-like receptors)Hormone ligand-binding receptors GPCR downstream signalling

via MyGene.info

Gene · Ensembl

luteinizing hormone/choriogonadotropin receptor

Symbol: LHCGR
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:48,686,774-48,755,731
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: LHCGR.png

Show 5 more facts

HomoloGene ID: 37276
exact match: identifiers.org/ncbigene/3973
genomic end: 48982880
genomic start: 48686774
cytogenetic location: 2p16.3

Sources (5)

via Wikidata · CC0

Available in 7 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 2 Gonadotropin-releasing hormone and gonadotropins G protein-coupled receptors Signal transduction