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myelin basic protein
Sign in to saveAlso known as MBP, myelin A1 protein, proline-rich proteoglycan 2, myelin membrane encephalitogenic protein, Golli-MBP
mammalian protein found in Homo sapiens
Protein · UniProt
Myelin basic protein
- Gene
- MBP
- Organism
- Homo sapiens (Human)
- Length
- 304 aa
- Molecular mass
- 33,117 Da
- Evidence
- 1: Evidence at protein level
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differe…
Swiss-Prot (reviewed) · via UniProt
Research
13,247 papers- Myelin basic protein: a multifunctional protein.Cellular and molecular life sciences : CMLS · 2006
- Myelin basic protein.Scandinavian journal of immunology. Supplement · 1982
- Myelin basic protein and TREM2 quantification in the CSF of patients with Multiple System Atrophy and other Parkinsonian conditions.Journal of neurology · 2024
- Structural homology of myelin basic protein and muscarinic acetylcholine receptor: Significance in the pathogenesis of complex regional pain syndrome.Molecular pain · 2018
- Myelin basic protein: structure, function and antigenic determinants.Immunological reviews · 1978
via PubMed
Clinical Trials
2 registered- PHASE2COMPLETEDEvaluation of an Altered Peptide Ligand (NBI-5788) in Patients With Relapsing Multiple Sclerosis (MS)Neurocrine Biosciences · NCT00079495
- NACOMPLETEDEfficacy and Mechanism of High-Dose Vitamin D Supplementation in Pediatric OAB-Dry: A Randomized Clinical Trial Integrating Urinary Myelin Basic Protein as a Theranostic BiomarkerXing Liu · NCT06489951