ARRB2

Also known as ARB2, ARR2, BARR2, Arrestin beta 2

protein-coding gene in the species Homo sapiens

Gene data

ARRB2

Name: arrestin beta 2
Type: protein-coding
Position: 4,710,393–4,721,500 (+)
Aliases: ARB2, ARR2, BARR2
Ensembl: ENSG00000141480
RefSeq RNA: NM_001257328.2, NM_001257329.2, NM_001257330.2, NM_001257331.2, NM_001330064.2
RefSeq protein: NP_001244257.1, NP_001244258.1, NP_001244259.1, NP_001244260.1, NP_001316993.1

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012].