MDM2
Sign in to saveAlso known as ACTFS, HDMX, hdm2, MDM2 proto-oncogene, LSKB
Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important negative regulator of the p53 tumor suppressor. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and as an inhibitor of p53 transcriptional activation.
Clinical Trials
33 registered- PHASE2RECRUITINGA Cancer Vaccine (STEMVAC) in Combination With Chemotherapy for the Treatment of PD-L1 Negative Metastatic Triple-Negative Breast CancerUniversity of Washington · NCT07078604
- PHASE2TERMINATEDMilademetan in Advanced/Metastatic Solid TumorsRain Oncology Inc · NCT05012397
- PHASE1TERMINATEDA Study of ALRN-6924 for Protection of Chemotherapy-Induced Side Effects in Patients With TP53-Mutant Breast CancerAileron Therapeutics, Inc. · NCT05622058
- PHASE1/PHASE2UNKNOWNKRT-232 in Combination With TL-895 for the Treatment of R/R MF and KRT-232 for the Treatment of JAKi Intolerant MFKartos Therapeutics, Inc. · NCT04640532
- PHASE1COMPLETEDA Study to Investigate the Bioequivalence or Relative Bioavailability of Three New Idasanutlin Tablet Variants Following Oral Administration in Participants With Solid TumorsHoffmann-La Roche · NCT03362723
- PHASE1TERMINATEDA Study of ALRN-6924 for the Prevention of Chemotherapy-induced Side Effects (Chemoprotection)Aileron Therapeutics, Inc. · NCT04022876
Wikidata facts
- Image
- Proteïna MDM2.gif
Show 5 more facts
- HomoloGene ID
- 1793
- exact match
- identifiers.org/ncbigene/4193
- genomic end
- 68845544
- genomic start
- 68808177
- cytogenetic location
- 12q15
via Wikidata · CC0
~7 min read
Article
10 sectionsContents
- Discovery and expression in tumor cells
- Ubiquitination target: p53
- E3 ligase activity
- Structure and function
- Regulation
- Interactions
- Mdm2 p53-independent role
- References
- Further reading
- External links
Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important negative regulator of the p53 tumor suppressor. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and as an inhibitor of p53 transcriptional activation.
== Discovery and expression in tumor cells ==