Calnexin
Sign in to saveAlso known as major histocompatibility complex class I antigen-binding protein p88, p90, epididymis secretory sperm binding protein, CANX, IP90
Calnexin (CNX) is a 67kDa integral protein (that appears variously as a 90kDa, 80kDa, or 75kDa band on western blotting depending on the source of the antibody) of the endoplasmic reticulum (ER). It consists of a large (50 kDa) N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short (90 residues), acidic cytoplasmic tail. In humans, calnexin is encoded by the gene CANX.
Protein · UniProt
Calnexin
- Gene
- CANX
- Organism
- Homo sapiens (Human)
- Length
- 592 aa
- Molecular mass
- 67,568 Da
- Evidence
- 1: Evidence at protein level
Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at…
Swiss-Prot (reviewed) · via UniProt
Research
1,942 papers- Calnexin, More Than Just a Molecular Chaperone.Cells · 2023
- Calnexin cycle - structural features of the ER chaperone system.The FEBS journal · 2020
- KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.Autophagy · 2022
- The ER protein CANX (calnexin)-mediated autophagy protects against alzheimer disease.Autophagy · 2025
- Calnexin promotes glioblastoma progression by inducing protective mitophagy through the MEK/ERK/BNIP3 pathway.Theranostics · 2025
via PubMed
Wikidata facts
- Instance of
- protein
- Image
- Calnexin 1JHN.png
Show 2 more facts
- found in taxon
- Homo sapiens
- exact match
- www.ncbi.nlm.nih.gov/protein/P27824
via Wikidata · CC0
~3 min read
Encyclopedic overview
5 sectionsContents
- Function
- Cofactors
- References
- External links
- Further reading
Calnexin (CNX) is a 67kDa integral protein (that appears variously as a 90kDa, 80kDa, or 75kDa band on western blotting depending on the source of the antibody) of the endoplasmic reticulum (ER). It consists of a large (50 kDa) N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short (90 residues), acidic cytoplasmic tail. In humans, calnexin is encoded by the gene CANX.
== Function ==
Excerpted from Wikipedia’s “Calnexin” article, available under the CC BY-SA 4.0 licence.