ficolin
Sign in to saveFicolins are pattern recognition receptors that bind to acetyl groups present in the carbohydrates of bacterial surfaces and mediate activation of the lectin pathway of the complement cascade.
Research
896 papers- Ficolin B secreted by alveolar macrophage exosomes exacerbates bleomycin-induced lung injury via ferroptosis through the cGAS-STING signaling pathway.Cell death & disease · 2023
- Ficolin-1 ameliorates pulmonary fibrosis via directly binding to TGF-β1.Journal of translational medicine · 2024
- Expansion of Fcγ Receptor IIIa-Positive Macrophages, Ficolin 1-Positive Monocyte-Derived Dendritic Cells, and Plasmacytoid Dendritic Cells Associated With Severe Skin Disease in Systemic Sclerosis.Arthritis & rheumatology (Hoboken, N.J.) · 2022
- Circulating Ficolin-2 and Ficolin-3 Form Heterocomplexes.Journal of immunology (Baltimore, Md. : 1950) · 2020
- Ficolin-A Protects Against Allergic Asthma via Suppressing ILC2-Drived Type 2 Inflammation.Allergy · 2026
via PubMed
~3 min read
Article
5 sectionsContents
- Structure
- Role in innate immunity
- Types of ficolin
- Clinical references
- References
Ficolins are pattern recognition receptors that bind to acetyl groups present in the carbohydrates of bacterial surfaces and mediate activation of the lectin pathway of the complement cascade.
== Structure == Ficolins (Fi+Col+Lin) are a group of oligomeric lectins with N-terminal collagen-like domain and a C-terminal fibrinogen-like domain. The primary ficolin structure contains 288 amino acids. The combination of collagen-like and fibrinogen-like domain allows the protein to form a basic subunit containing a triple helical tail and a trio of globular heads.