Mannose binding lectin 2
Sign in to saveAlso known as Mannose-binding lectin, Mannan-binding protein, mannan-binding lectin, mannose-binding lectin (protein C) 2, soluble (opsonic defect), mannose-binding lectin 2, soluble (opsonic defect), mannose-binding protein C, collectin-1, MBL2
mammalian protein found in Homo sapiens
Protein · UniProt
Mannose-binding protein C
- Gene
- MBL2
- Organism
- Homo sapiens (Human)
- Length
- 248 aa
- Molecular mass
- 26,144 Da
- Evidence
- 1: Evidence at protein level
Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:14515269, PubMed:22966085, PubMed:7634089, PubMed:9087411). Specifically recognizes and binds the mannose moiety of carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed:22966085, PubMed:2573758, PubMed:6643429, PubMed:808…
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
15 registered- COMPLETEDLow Plasma Mannose Binding Lectin (p-MBL) Level is a Risk Factor for Recurrent Pregnancy Loss (RPL)Aalborg University Hospital · NCT04017754
- NACOMPLETEDInfluence of Periodontal Disease Treatment on Serum Levels of Sirtuin 1 and Mannose-binding LectinInCor Heart Institute · NCT03753451
- WITHDRAWNLectine Pathway in Unstable Carotid PlaqueFondazione Policlinico Universitario Agostino Gemelli IRCCS · NCT03822195
- COMPLETEDStudy of the Level of a Protein Which Could Predict the Development of a Fungal Infection in Patients With Acute LeukemiaCentre Hospitalier Universitaire Dijon · NCT02823132
- RECRUITINGAssociation Between Plasma Level of Mannose Binding Lectin and Human ReproductionAalborg University Hospital · NCT05169541
- NACOMPLETEDThe Effect of Weight Loss on Serum Mannose-Binding Lectin(MBL) LevelsUniversity of Aarhus · NCT00854412