Calreticulin

Also known as epididymis secretory sperm binding protein Li 99n, CRP55, HACBP, ERp60, endoplasmic reticulum resident protein 60, CALR, calregulin

Calreticulin also known as calregulin, CRP55, CaBP3, calsequestrin-like protein, and endoplasmic reticulum resident protein 60 (ERp60) is a protein that in humans is encoded by the CALR gene.

Protein · UniProt

Calreticulin

Gene: CALR
Organism: Homo sapiens (Human)
Length: 417 aa
Molecular mass: 48,142 Da
Evidence: 1: Evidence at protein level

Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes…

3D-structureAcetylationCalciumChaperoneCytoplasmCytoplasmic vesicleDirect protein sequencingDisulfide bond

View on UniProt →

Swiss-Prot (reviewed) · via UniProt

Clinical Trials

5 registered

UNKNOWN
Global Coagulation Assessment in Portal Vein Thrombosis and Budd-Chiari SyndromePost Graduate Institute of Medical Education and Research, Chandigarh · NCT05123326
EARLY_PHASE1TERMINATED
CPAP in Treating Obstructive Sleep Apnea in Patients With Polycythemia Vera or Essential ThrombocythemiaUniversity of Utah · NCT03972943
PHASE3NOT_YET_RECRUITING
A Phase 3 Study of INCA033989 Versus Best Available Therapy in Participants With Essential ThrombocythemiaIncyte Corporation · NCT07623200
PHASE1RECRUITING
A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative NeoplasmsJanssen Research & Development, LLC · NCT06150157
NAUNKNOWN
Study of the Response to a Neoadjuvant Chemotherapy Based on the Antitumor Immune Response in Localized Breast CancerCentre Leon Berard · NCT01440413

via ClinicalTrials.gov

Wikidata facts

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exact match: purl.uniprot.org/uniprot/P27797

Sources (4)

via Wikidata · CC0

~5 min read

Article

8 sections

Contents

Function
Transcription regulation
Clinical significance
Role in cancer
Interactions
References
Further reading
External links

Calreticulin also known as calregulin, CRP55, CaBP3, calsequestrin-like protein, and endoplasmic reticulum resident protein 60 (ERp60) is a protein that in humans is encoded by the CALR gene.

Calreticulin is a multifunctional soluble protein that binds Ca2+ ions (a second messenger in signal transduction), rendering them inactive. The Ca2+ is bound with low affinity, but high capacity, and can be released on a signal (see inositol trisphosphate). Calreticulin is located in storage compartments associated with the endoplasmic reticulum and is considered an ER resident protein.