MAPK10

Also known as JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK, mitogen-activated protein kinase 10

Mitogen-activated protein kinase 10 also known as c-Jun N-terminal kinase 3 (JNK3) is an enzyme that in humans is encoded by the MAPK10 gene.

Gene data

MAPK10

Name: mitogen-activated protein kinase 10
Type: protein-coding
Position: 85,990,007–86,594,625 (−)
Aliases: JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK
Ensembl: ENSG00000109339
RefSeq RNA: NM_001318067.1, NM_001318068.1, NM_001318069.2, NM_001351624.2, NM_001351625.3
RefSeq protein: NP_001304996.1, NP_001304997.1, NP_001304998.1, NP_001338553.1, NP_001338554.1

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017].