DVL2
Sign in to saveAlso known as dishevelled segment polarity protein 2
Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene.
In the Vinony graph
Within Vinony's link graph, DVL2 is referenced by 8 other articles, and connects out to PubMed, human chromosome 17 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 17.
Its subject is documented across 6 Wikipedia language editions.
Gene data
DVL2- Name
- dishevelled segment polarity protein 2
- Type
- protein-coding
- Position
- 7,225,338–7,234,538 (−)
- Ensembl
- ENSG00000004975
- RefSeq RNA
- NM_004422.3, XM_005256502.3, XM_047435518.1, XM_047435519.1, XM_047435520.1
- RefSeq protein
- NP_004413.1, XP_005256559.1, XP_047291474.1, XP_047291475.1, XP_047291476.1
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
dishevelled segment polarity protein 2
- Symbol
- DVL2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:7,225,338-7,234,538
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein DVL2 PDB 1l6o.png
Show 8 more facts
- HomoloGene ID
- 20927
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1856
- genomic end
- 7234517
- genomic start
- 7225342
- chromosome
- human chromosome 17
- cytogenetic location
- 17p13.1
- expressed in
- ganglionic eminence
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- See also
- References
- Further reading
Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene.
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
Excerpted from Wikipedia’s “DVL2” article, available under the CC BY-SA 4.0 licence.