DAB2
Sign in to saveAlso known as DOC-2, DOC2, DAB2, clathrin adaptor protein, DAB adaptor protein 2
Disabled homolog 2 is a protein that in humans is encoded by the DAB2 gene.
Gene data
DAB2- Name
- DAB adaptor protein 2
- Type
- protein-coding
- Aliases
- DOC-2, DOC2
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
via MyGene.info
Gene · Ensembl
DAB adaptor protein 2
- Symbol
- DAB2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:39,371,675-39,462,300
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein DAB2 PDB 1m7e.png
Show 5 more facts
- HomoloGene ID
- 1026
- exact match
- identifiers.org/ncbigene/1601
- genomic end
- 39462402
- genomic start
- 39371780
- cytogenetic location
- 5p13.1
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Function
- Interactions
- References
- Further reading
Disabled homolog 2 is a protein that in humans is encoded by the DAB2 gene.
== Function ==