Also known as DOC-2, DOC2, DAB2, clathrin adaptor protein, DAB adaptor protein 2
Disabled homolog 2 is a protein that in humans is encoded by the DAB2 gene.
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
via MyGene.info
Disabled homolog 2 is a protein that in humans is encoded by the DAB2 gene.
== Function ==
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Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).