DAB2

Name

DAB adaptor protein 2

Type

protein-coding

Aliases

DOC-2, DOC2

This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

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Gene · Ensembl

DAB adaptor protein 2

Symbol

DAB2

Biotype

Protein coding

Organism

Homo sapiens

Location

5:39,371,675-39,462,300

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein DAB2 PDB 1m7e.png

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