SMAD2
Sign in to saveAlso known as JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2, SMAD family member 2, LDS6
Mothers against decapentaplegic homolog 2, also known as SMAD family member 2 or SMAD2, is a protein that in humans is encoded by the SMAD2 gene. MAD homolog 2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways.
Gene data
SMAD2- Name
- SMAD family member 2
- Type
- protein-coding
- Position
- 47,808,957–47,931,569 (−)
- Aliases
- CHTD8, JV18, JV18-1, LDS6, MADH2, MADR2, hMAD-2, hSMAD2
- Ensembl
- ENSG00000175387
- RefSeq RNA
- NM_001003652.4, NM_001135937.3, NM_005901.6, XM_017025749.2, XM_047437507.1
- RefSeq protein
- NP_001003652.1, NP_001129409.1, NP_005892.1, XP_016881238.1, XP_047293463.1
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
SMAD family member 2
- Symbol
- SMAD2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 18:47,808,957-47,931,569
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein SMAD2 PDB 1dev.png
Show 5 more facts
- HomoloGene ID
- 21197
- exact match
- identifiers.org/ncbigene/4087
- genomic end
- 45457515
- genomic start
- 45357922
- cytogenetic location
- 18q21.1
via Wikidata · CC0
~3 min read
Article
5 sectionsContents
- Function
- Nomenclature
- Interactions
- References
- Further reading
Mothers against decapentaplegic homolog 2, also known as SMAD family member 2 or SMAD2, is a protein that in humans is encoded by the SMAD2 gene. MAD homolog 2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways.
== Function ==