MYC proto-oncogene, bHLH transcription factor
Also known as avian myelocytomatosis viral oncogene homolog, MYC, bHLHe39, transcription factor p64, myc-related translation/localization regulatory factor, v-myc myelocytomatosis viral oncogene homolog, v-myc avian myelocytomatosis viral oncogene homolog, proto-oncogene c-Myc
Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to homology with the viral gene v-myc.
Key facts
- Protein.name
- MYCN proto-oncogene, bHLH transcription factor
- Protein.Symbol
- MYCN
- Protein.AltSymbols
- LMYC, MYCL1, bHLHe38, L-Myc, v-myc
- Protein.EntrezGene
- 4613
- Protein.HGNCid
- 7559
- Protein.OMIM
- 164840
- Protein.RefSeq
- NM_005378
- Protein.UniProt
- V
- Protein.Chromosome
- 2
- Protein.Arm
- p
- Protein.Band
- 24.3
- Protein.Wikidata
- Q14906753
via Wikipedia infobox
~14 min read
Article
13 sectionsContents
- Discovery
- Structure
- Function
- Myc-nick
- Clinical significance
- MYC rearrangements
- Animal models
- Relationship to stem cells
- Interactions
- See also
- References
- Further reading
- External links
Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to homology with the viral gene v-myc.
In cancer, c-myc is often constitutively (persistently) expressed. This leads to the increased expression of many genes, some of which are involved in cell proliferation, contributing to the formation of cancer. A common human translocation involving c-myc is critical to the development of most cases of Burkitt lymphoma. Constitutive upregulation of Myc genes have also been observed in carcinoma of the cervix, colon, breast, lung and stomach.