JAM3

Also known as JAM-2, JAM-3, JAM-C, JAMC, junctional adhesion molecule 3

Junctional adhesion molecule C is a protein that in humans is encoded by the JAM3 gene.

Gene data

JAM3

Name: junctional adhesion molecule 3
Type: protein-coding
Position: 134,068,998–134,152,001 (+)
Aliases: JAM-2, JAM-3, JAM-C, JAMC
Ensembl: ENSG00000166086
RefSeq RNA: NM_001205329.2, NM_032801.5
RefSeq protein: NP_001192258.1, NP_116190.3

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011].