CTCF
Also known as MRD21, CCCTC-binding factor, FAP108, CFAP108
Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V(D)J recombination and regulation of chromatin architecture.
Gene data
CTCF- Name
- CCCTC-binding factor
- Type
- protein-coding
- Position
- 67,561,831–67,639,189 (+)
- Aliases
- CFAP108, FAP108, MRD21
- Ensembl
- ENSG00000102974
- RefSeq RNA
- NM_001191022.2, NM_001363916.2, NM_001438968.1, NM_001438969.1, NM_006565.4
- RefSeq protein
- NP_001177951.1, NP_001350845.1, NP_001425897.1, NP_001425898.1, NP_006556.1
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
Article
13 sectionsContents
- Discovery
- Function
- Evolution
- Observed activity
- Transcriptional regulation
- Insulation
- Regulation of chromatin architecture
- Regulation of RNA splicing
- DNA binding
- Protein-protein interactions
- References
- Further reading
- External links
Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V(D)J recombination and regulation of chromatin architecture.
== Discovery == CCCTC-Binding factor or CTCF was initially discovered as a negative regulator of the chicken c-myc gene. This protein was found to be binding to three regularly spaced repeats of the core sequence CCCTC and thus was named CCCTC binding factor.