SMAD family member 4
Also known as SMAD 4, deleted in pancreatic carcinoma locus 4, SMAD4, deletion target in pancreatic carcinoma 4, mothers against decapentaplegic, Drosophila, homolog of, 4, hSMAD4, SMAD, mothers against DPP homolog 4, mothers against decapentaplegic homolog 4
SMAD4, also called SMAD family member 4, Mothers against decapentaplegic homolog 4, or DPC4 (deleted in pancreatic cancer 4) is a highly conserved protein present in all metazoans. It belongs to the SMAD family of transcription factor proteins, which act as mediators of TGF-β signal transduction. The TGFβ family of cytokines regulates critical processes during the lifecycle of metazoans, with important roles during embryo development, tissue homeostasis, regeneration, and immune regulation.
Research
1,861 papers- Smad4/DPC4.Journal of clinical pathology · 2018
- Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.Nature medicine · 2015
- Myhre syndrome.Clinical genetics · 2014
- The Smad pathway.Cytokine & growth factor reviews · 2000
- Intestinal stem cells.Journal of cellular and molecular medicine · 2005
via PubMed
Clinical Trials
3 registered~11 min read
Article
11 sectionsContents
- Gene
- Protein
- Structures
- MH1 domain complexes with DNA motifs
- MH2 domain complexes
- Nomenclature and origin of name
- Function and action mechanism
- Clinical significance
- References
- Further reading
- External links
SMAD4, also called SMAD family member 4, Mothers against decapentaplegic homolog 4, or DPC4 (deleted in pancreatic cancer 4) is a highly conserved protein present in all metazoans. It belongs to the SMAD family of transcription factor proteins, which act as mediators of TGF-β signal transduction. The TGFβ family of cytokines regulates critical processes during the lifecycle of metazoans, with important roles during embryo development, tissue homeostasis, regeneration, and immune regulation.
SMAD 4 belongs to the co-SMAD group (common mediator SMAD), the second class of the SMAD family. SMAD4 is the only known co-SMAD in most metazoans. It also belongs to the Dwarfin family of proteins that modulate members of the TGFβ protein superfamily, a family of proteins that all play a role in the regulation of cellular responses. Mammalian SMAD4 is a homolog of the Drosophila protein "Mothers against decapentaplegic" named Medea.