SMAD1
Sign in to saveAlso known as BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1, SMAD family member 1
Mothers against decapentaplegic homolog 1 also known as SMAD family member 1 or SMAD1 is a protein that in humans is encoded by the SMAD1 gene.
Gene data
SMAD1- Name
- SMAD family member 1
- Type
- protein-coding
- Position
- 145,480,769–145,559,191 (+)
- Aliases
- BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1
- Ensembl
- ENSG00000170365
- RefSeq RNA
- NM_001003688.1, NM_001354811.1, NM_001354812.1, NM_001354813.1, NM_001354814.1
- RefSeq protein
- NP_001003688.1, NP_001341740.1, NP_001341741.1, NP_001341742.1, NP_001341743.1
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
SMAD family member 1
- Symbol
- SMAD1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:145,480,769-145,559,191
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~2 min read
Encyclopedic overview
4 sectionsContents
- Nomenclature
- Function
- References
- External links
Mothers against decapentaplegic homolog 1 also known as SMAD family member 1 or SMAD1 is a protein that in humans is encoded by the SMAD1 gene.
==Nomenclature== SMAD1 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The name is a combination of the two; and based on a tradition of such unusual naming within the gene research community.
Excerpted from Wikipedia’s “SMAD1” article, available under the CC BY-SA 4.0 licence.