Also known as OP-1, bone morphogenetic protein 7
protein-coding gene in the species Homo sapiens
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016].
Biological process
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via MyGene.info
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Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).