GDF7
Sign in to saveAlso known as BMP12, growth differentiation factor 7
Growth differentiation factor 7 (GDF7) is a protein that in humans is encoded by the GDF7 gene.
Gene data
GDF7- Name
- growth differentiation factor 7
- Type
- protein-coding
- Aliases
- BMP12
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma. [provided by RefSeq, Sep 2016].
via MyGene.info
Gene · Ensembl
growth differentiation factor 7
- Symbol
- GDF7
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:20,667,134-20,679,243
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- exact match
- identifiers.org/ncbigene/151449
- HomoloGene ID
- 32177
- genomic end
- 20679243
- genomic start
- 20667144
- cytogenetic location
- 2p24.1
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Growth differentiation factor 7 (GDF7) is a protein that in humans is encoded by the GDF7 gene.
GDF7 belongs to the transforming growth factor beta superfamily that is specifically found in a signaling center known as the roof plate that is located in the developing nervous system of embryos. The roof plate is required for the generation of several classes of spinal cord dorsal interneurons; GDF7 specifically induces the formation of sensory neurons in the dorsal spinal cord from neural crest cells by generating signals within the roof plate.