GDF15
Sign in to saveAlso known as GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB, growth differentiation factor 15
Growth/differentiation factor 15 is a protein that in humans is encoded by the GDF15 gene. GDF15 was first identified as Macrophage inhibitory cytokine-1 (MIC-1).
Gene data
GDF15- Name
- growth differentiation factor 15
- Type
- protein-coding
- Aliases
- GDF-15, HG, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Aug 2016].
via MyGene.info
Gene · Ensembl
growth differentiation factor 15
- Symbol
- GDF15
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:18,374,731-18,389,176
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- GDF15.png
Show 5 more facts
- HomoloGene ID
- 3576
- exact match
- identifiers.org/ncbigene/9518
- genomic end
- 18499986
- genomic start
- 18485541
- cytogenetic location
- 19p13.11
via Wikidata · CC0
~1 min read
Article
5 sectionsContents
- Function
- Clinical significance
- Therapeutics development
- References
- External links
Growth/differentiation factor 15 is a protein that in humans is encoded by the GDF15 gene. GDF15 was first identified as Macrophage inhibitory cytokine-1 (MIC-1).
It is a protein belonging to the transforming growth factor beta superfamily. Under normal conditions, GDF15 is expressed in low concentrations in most organs and is upregulated because of injury to organs such as the liver, kidney, heart and lung. Its chemical formula is:C1076H1710O316N324S24.