GDF3
Sign in to saveAlso known as KFS3, MCOP7, MCOPCB6, growth differentiation factor 3
Growth differentiation factor-3 (GDF3), also known as Vg-related gene 2 (Vgr-2) is protein that in humans is encoded by the GDF3 gene. GDF3 belongs to the transforming growth factor beta (TGF-β) superfamily. It has high similarity to other TGF-β superfamily members including Vg1 (found in frogs) and GDF1.
Gene data
GDF3- Name
- growth differentiation factor 3
- Type
- protein-coding
- Aliases
- KFS3, MCOP7, MCOPCB6
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role ocular and skeletal development. Mutations in this gene are associated with microphthalmia, coloboma, and skeletal abnormalities in human patients. [provided by RefSeq, Aug 2016].
via MyGene.info
Gene · Ensembl
growth differentiation factor 3
- Symbol
- GDF3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:7,689,784-7,695,807
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 7336
- genomic start
- 7842378
- exact match
- identifiers.org/ncbigene/9573
- cytogenetic location
- 12p13.31
- genomic end
- 7695775
Sources (3)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Tissue distribution
- Function
- References
- Further reading
Growth differentiation factor-3 (GDF3), also known as Vg-related gene 2 (Vgr-2) is protein that in humans is encoded by the GDF3 gene. GDF3 belongs to the transforming growth factor beta (TGF-β) superfamily. It has high similarity to other TGF-β superfamily members including Vg1 (found in frogs) and GDF1.
== Tissue distribution ==