GDF11

Also known as BMP-11, BMP11, growth differentiation factor 11, VHO

Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP-11), is a protein that in humans is encoded by the growth differentiation factor 11 gene. GDF11 is a member of the Transforming growth factor beta family.

Gene data

GDF11

Name: growth differentiation factor 11
Type: protein-coding
Aliases: BMP-11, BMP11, VHO

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. [provided by RefSeq, Aug 2016].

via MyGene.info

Gene · Ensembl

growth differentiation factor 11

Symbol: GDF11
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:55,743,122-55,757,264
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 21183
exact match: identifiers.org/ncbigene/10220
genomic end: 55757264
genomic start: 55743122
cytogenetic location: 12q13.2

Sources (4)

via Wikidata · CC0

~4 min read

Article

7 sections

Contents

Tissue distribution
Function
Effects on cell growth and differentiation
Human studies
References
Further reading
External links

GDF11 acts as a cytokine and its sequence is highly conserved between in humans, mice and rats. The bone morphogenetic protein group is characterized by a polybasic proteolytic processing site, which is cleaved to produce a protein containing seven conserved cysteine residues.