BMP4

Name

bone morphogenetic protein 4

Type

protein-coding

Position

53,949,736–53,958,761 (−)

Aliases

BMP2B, BMP2B1, MCOPS6, OFC11, ZYME

Ensembl

ENSG00000125378

RefSeq RNA

NM_001202.6, NM_001347912.1, NM_001347913.2, NM_001347914.2, NM_001347915.2

RefSeq protein

NP_001193.2, NP_001334841.1, NP_001334842.1, NP_001334843.1, NP_001334844.1

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016].

via MyGene.info

Gene · Ensembl

bone morphogenetic protein 4

Symbol

BMP4

Biotype

Protein coding

Organism

Homo sapiens

Location

14:53,944,482-53,958,761

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

via Wikidata · CC0