SMAD7

Also known as CRCS3, MADH7, MADH8, SMAD family member 7

Mothers against decapentaplegic homolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene.

Gene data

SMAD7

Name: SMAD family member 7
Type: protein-coding
Position: 48,919,853–48,952,020 (−)
Aliases: CRCS3, MADH7, MADH8
Ensembl: ENSG00000101665
RefSeq RNA: NM_001190821.2, NM_001190822.2, NM_001190823.2, NM_005904.4, XM_047437509.1
RefSeq protein: NP_001177750.1, NP_001177751.1, NP_001177752.1, NP_005895.1, XP_047293465.1

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].

Pathways

TGF-beta signaling pathway - Homo sapiens (human)Hippo signaling pathway - Homo sapiens (human)Cytokine Signaling in Immune system Signal Transduction Signal Transduction Immune System Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex Signaling by BMP Generic Transcription Pathway

via MyGene.info

Gene · Ensembl

SMAD family member 7

Symbol: SMAD7
Biotype: Protein coding
Organism: Homo sapiens
Location: 18:48,919,853-48,952,026
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: SMURF2 SMAD7 complex.png

Show 5 more facts

HomoloGene ID: 4314
exact match: identifiers.org/ncbigene/4092
genomic end: 48950965
genomic start: 46446223
cytogenetic location: 18q21.1

Sources (6)

via Wikidata · CC0

~4 min read

Article

7 sections

Contents

Structure
Function
Role in cancer
Use in Pharmacology
Interactions
References
Further reading

Mothers against decapentaplegic homolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene.

SMAD7 is a protein that, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of ligands. Like many other TGFβ family members, SMAD7 is involved in cell signalling. It is a TGFβ type 1 receptor antagonist. It blocks TGFβ1 and activin associating with the receptor, blocking access to SMAD2. It is an inhibitory SMAD (I-SMAD) and is enhanced by SMURF2.