GDF1

Also known as DORV, DTGA3, RAI, growth differentiation factor 1, CHTD6, UOG1, LASS1, CERS1

Growth differentiation factor 1 (GDF1) is a protein that in humans is encoded by the GDF1 gene.

Gene data

GDF1

Name: growth differentiation factor 1
Type: protein-coding
Aliases: CHTD6, DORV, DTGA3, RAI

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. The encoded protein is translated from a bicistronic mRNA that also encodes ceramide synthase 1. Mutations in this gene are associated with several congenital cardiovascular malformations. [provided by RefSeq, Jul 2016].

via MyGene.info

Gene · Ensembl

growth differentiation factor 1

Symbol: GDF1
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:18,868,545-18,896,158
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

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HomoloGene ID: 105644
exact match: identifiers.org/ncbigene/2657
cytogenetic location: 19p13.11
genomic start: 18979361
genomic end: 19007536

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Growth differentiation factor 1 (GDF1) is a protein that in humans is encoded by the GDF1 gene.

GDF1 belongs to the transforming growth factor beta superfamily that has a role in left-right patterning and mesoderm induction during embryonic development. It is found in the brain, spinal cord and peripheral nerves of embryos.