BMP2
Sign in to saveAlso known as BDA2, BMP2A, bone morphogenetic protein 2, SSFSC, SSFSC1
protein-coding gene in the species Homo sapiens
Gene data
BMP2- Name
- bone morphogenetic protein 2
- Type
- protein-coding
- Position
- 6,767,686–6,780,251 (+)
- Aliases
- BDA2, BMP2A, SSFSC, SSFSC1
- Ensembl
- ENSG00000125845
- RefSeq RNA
- NM_001200.4
- RefSeq protein
- NP_001191.1
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
bone morphogenetic protein 2
- Symbol
- BMP2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:6,767,679-6,782,614
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- BMP2.png
Show 6 more facts
- HomoloGene ID
- 926
- exact match
- identifiers.org/ncbigene/650
- genomic end
- 6780246
- genomic start
- 6767686
- cytogenetic location
- 20p12.3
- Commons category
- Bone morphogenetic protein-2 (BMP-2)
via Wikidata · CC0
Available in 10 languages
via Wikidata sitelinks · CC0