GDF10

Also known as BMP-3b, BMP3B, growth differentiation factor 10, BIP

Growth differentiation factor 10 (GDF10) also known as bone morphogenetic protein 3B (BMP-3B) is a protein that in humans is encoded by the GDF10 gene.

Gene data

GDF10

Name: growth differentiation factor 10
Type: protein-coding
Aliases: BIP, BMP-3b, BMP3B

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer. [provided by RefSeq, Jul 2016].

via MyGene.info

Gene · Ensembl

growth differentiation factor 10

Symbol: GDF10
Biotype: Protein coding
Organism: Homo sapiens
Location: 10:47,300,060-47,313,580
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

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HomoloGene ID: 3640
exact match: identifiers.org/ncbigene/2662
genomic start: 47300197
genomic end: 47313577
cytogenetic location: 10q11.22

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Growth differentiation factor 10 (GDF10) also known as bone morphogenetic protein 3B (BMP-3B) is a protein that in humans is encoded by the GDF10 gene.

GDF10 belongs to the transforming growth factor beta superfamily that is closely related to bone morphogenetic protein-3 (BMP3). It plays a role in head formation and may have multiple roles in skeletal morphogenesis. GDF10 is also known as BMP-3b, with GDF10 and BMP3 regarded as a separate subgroup within the TGF-beta superfamily.