TUSC3

Also known as D8S1992, M33, MRT22, MRT7, N33, OST3A, tumor suppressor candidate 3, MagT2

Tumor suppressor candidate 3 is a protein that in humans is encoded by the TUSC3 gene.

In the Vinony graph

Vinony's link graph records 4 inbound references to TUSC3, and connects out to PubMed, human chromosome 8 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 8.

Vinony links it to 6 Wikipedia language editions.

Gene data

TUSC3

Name: tumor suppressor candidate 3
Type: protein-coding
Aliases: D8S1992, M33, MRT22, MRT7, MagT2, N33, OST3A, SLC58A2

This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform. [provided by RefSeq, Oct 2017].

via MyGene.info

Gene · Ensembl

tumor suppressor candidate 3

Symbol: TUSC3
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:15,417,215-15,789,603
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: 4m91.png

Show 8 more facts

HomoloGene ID: 6937
genomic start: 15417215
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/7991
genomic end: 15624158
chromosome: human chromosome 8
cytogenetic location: 8p22
genetic association: intellectual disability

Sources (7)

via Wikidata · CC0

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Encyclopedic overview

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Contents

References
Further reading

Tumor suppressor candidate 3 is a protein that in humans is encoded by the TUSC3 gene.

This gene is a candidate tumor suppressor gene. It is located within a deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene.

Excerpted from Wikipedia’s “TUSC3” article, available under the CC BY-SA 4.0 licence.