TRAF3

Also known as CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1, TNF receptor associated factor 3, RNF118

TNF receptor-associated factor (TRAF3) is a protein that in humans is encoded by the TRAF3 gene. ''''''

Gene data

TRAF3

Name: TNF receptor associated factor 3
Type: protein-coding
Position: 102,777,326–102,911,500 (+)
Aliases: CAP-1, CD40bp, CRAF1, IIAE5, IMD132A, IMD132B, LAP1, RNF118
Ensembl: ENSG00000131323
RefSeq RNA: NM_001199427.2, NM_001385142.1, NM_001385143.1, NM_001446041.1, NM_001446042.1
RefSeq protein: NP_001186356.1, NP_001372071.1, NP_001372072.1, NP_001432970.1, NP_001432971.1

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. The protein also plays a role in the regulation of antiviral response. Mutations in this are associated with Encephalopathy, acute, infection-induced, herpes-specific 5. [provided by RefSeq, Jul 2020].