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CD27 molecule
Sign in to saveAlso known as CD27, CD27 antigen, CD27L receptor, tumor necrosis factor receptor superfamily, member 7, T-cell activation antigen CD27, T14, T cell activation antigen S152, Tumor necrosis factor receptor superfamily member 7
CD27 is a member of the tumor necrosis factor receptor superfamily. It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule, and is the target of an anti-cancer drug in clinical trials.
Protein · UniProt
CD27 antigen
- Gene
- CD27
- Organism
- Homo sapiens (Human)
- Length
- 260 aa
- Molecular mass
- 29,137 Da
- Evidence
- 1: Evidence at protein level
Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells (PubMed:28011863). The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells (PubMed:28011863). Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory (PubMed:38354704). In addition, activation by CD70 on earl…
Swiss-Prot (reviewed) · via UniProt
Research
1,005 papers- OMIP-060: 30-Parameter Flow Cytometry Panel to Assess T Cell Effector Functions and Regulatory T Cells.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2019
- CD8(+)HLA-DR(+)CD27(+) T cells define a population of naturally occurring regulatory precursors in humans.Science advances · 2025
- CD27 is a signal-transducing molecule involved in CD45RA+ naive T cell costimulation.Journal of immunology (Baltimore, Md. : 1950) · 1994
- Human Atypical B Cells. An Overview.Immunological reviews · 2025
- CD27(+) microparticle interactions and immunoregulation of CD4(+) T lymphocytes.Frontiers in immunology · 2023
via PubMed
~2 min read
Article
9 sectionsContents
- Expression
- Function
- Clinical significance
- As a drug target
- Interactions
- Mutations
- References
- Further reading
- External links
CD27 is a member of the tumor necrosis factor receptor superfamily. It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule, and is the target of an anti-cancer drug in clinical trials.
== Expression == During mouse embryonic development, specific (medium) expression levels of CD27 (in addition to high cKit, medium Gata2, and high CD31 expression levels) define the very first adult definitive hematopoietic stem cells generated in the aorta-gonad-mesonephros region. Furthermore, CD27 is expressed on both naïve and activated effector T cells as well as NK cells and activated B cells. It is a type I transmembrane protein with cysteine-rich domains, but once T cells have become activated, a soluble form of CD27 can be shed.