GRB10
Sign in to saveAlso known as GRB-IR, Grb-10, IRBP, MEG1, RSS, growth factor receptor bound protein 10
Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene.
Gene data
GRB10- Name
- growth factor receptor bound protein 10
- Type
- protein-coding
- Position
- 50,590,063–50,793,486 (−)
- Aliases
- GRB-IR, Grb-10, IRBP, MEG1, RSS
- Ensembl
- ENSG00000106070
- RefSeq RNA
- NM_001001549.3, NM_001001550.3, NM_001001555.3, NM_001350814.2, NM_001350815.2
- RefSeq protein
- NP_001001549.1, NP_001001550.1, NP_001001555.1, NP_001337743.1, NP_001337744.1
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
growth factor receptor bound protein 10
- Symbol
- GRB10
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:50,590,063-50,793,486
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein GRB10 PDB 1nrv.png
Show 9 more facts
- HomoloGene ID
- 3882
- genetic association
- systemic scleroderma
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2887
- genomic end
- 50861159
- genomic start
- 50657760
- chromosome
- human chromosome 7
- cytogenetic location
- 7p12.1
- Commons category
- Growth factor receptor-bound protein 10, GRB10
Sources (8)
via Wikidata · CC0
~1 min read
Encyclopedic overview
6 sectionsContents
- Function
- Animal studies
- Interactions
- References
- Further reading
- External links
Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene.
== Function == The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors (e.g., IGF1R and IGF2R). Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.
Excerpted from Wikipedia’s “GRB10” article, available under the CC BY-SA 4.0 licence.