GRB10

Also known as GRB-IR, Grb-10, IRBP, MEG1, RSS, growth factor receptor bound protein 10

Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene.

Gene data

GRB10

Name: growth factor receptor bound protein 10
Type: protein-coding
Aliases: GRB-IR, Grb-10, IRBP, MEG1, RSS

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010].

via MyGene.info

Gene · Ensembl

growth factor receptor bound protein 10

Symbol: GRB10
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:50,590,063-50,793,486
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein GRB10 PDB 1nrv.png

Show 6 more facts

HomoloGene ID: 3882
exact match: identifiers.org/ncbigene/2887
genomic end: 50861159
genomic start: 50657760
cytogenetic location: 7p12.1
Commons category: Growth factor receptor-bound protein 10, GRB10

Sources (8)

via Wikidata · CC0

~1 min read

Article

6 sections

Contents

Function
Animal studies
Interactions
References
Further reading
External links

Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene.

== Function == The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors (e.g., IGF1R and IGF2R). Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.