Also known as entrez:5829, paxillin
Paxillin is a protein that in humans is encoded by the PXN gene. Paxillin is expressed at focal adhesions of non-striated cells and at costameres of striated muscle cells, and it functions to adhere cells to the extracellular matrix. Mutations in PXN as well as abnormal expression of paxillin protein has been implicated in the progression of various cancers.
Gene data
PXN- Name
- paxillin
- Type
- protein-coding
- Position
- 120,210,439–120,265,795 (−)
- Ensembl
- ENSG00000089159
- RefSeq RNA
- NM_001080855.3, NM_001243756.2, NM_001385981.1, NM_001385982.1, NM_001385983.1
- RefSeq protein
- NP_001074324.1, NP_001230685.1, NP_001372910.1, NP_001372911.1, NP_001372912.1
This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
paxillin
- Symbol
- PXN
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:120,210,439-120,265,800
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein PXN PDB 1KKY.png
Show 5 more facts
- HomoloGene ID
- 37697
- exact match
- identifiers.org/ncbigene/5829
- genomic end
- 120703574
- genomic start
- 120648250
- cytogenetic location
- 12q24.23
via Wikidata · CC0
~6 min read
Article
7 sectionsContents
- Structure
- Function
- Clinical significance
- Interactions
- References
- Further reading
- External links
Paxillin is a protein that in humans is encoded by the PXN gene. Paxillin is expressed at focal adhesions of non-striated cells and at costameres of striated muscle cells, and it functions to adhere cells to the extracellular matrix. Mutations in PXN as well as abnormal expression of paxillin protein has been implicated in the progression of various cancers.
== Structure ==