integrin subunit alpha 4

Also known as 269C wild type, integrin alpha-IV, CD49 antigen-like family member D, very late activation protein 4 receptor, alpha 4 subunit, alpha 4 subunit of VLA-4 receptor, antigen CD49D, alpha-4 subunit of VLA-4 receptor, VLA-4 subunit alpha, integrin alpha-4

mammalian protein found in Homo sapiens

Protein · UniProt

Integrin alpha-4

Gene: ITGA4
Organism: Homo sapiens (Human)
Length: 1,032 aa
Molecular mass: 114,900 Da
Evidence: 1: Evidence at protein level

Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:I…

3D-structureAlternative splicingCalciumCell adhesionDirect protein sequencingDisulfide bondGlycoproteinIntegrin

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Swiss-Prot (reviewed) · via UniProt