IRF3

Name

interferon regulatory factor 3

Type

protein-coding

Position

49,659,569–49,665,861 (−)

Aliases

IIAE7

Ensembl

ENSG00000126456

RefSeq RNA

NM_001197122.2, NM_001197123.2, NM_001197124.2, NM_001197125.2, NM_001197126.2

RefSeq protein

NP_001184051.1, NP_001184052.1, NP_001184053.1, NP_001184054.1, NP_001184055.1

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7. [provided by RefSeq, Sep 2020].