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GeneQ14914339· pop 7· linked from 893 articles

IRF3

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Also known as entrez:3661, IIAE7, interferon regulatory factor 3

Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor.

Gene data

IRF3

Name: interferon regulatory factor 3
Type: protein-coding
Position: 49,659,569–49,665,861 (−)
Aliases: IIAE7
Ensembl: ENSG00000126456
RefSeq RNA: NM_001197122.2, NM_001197123.2, NM_001197124.2, NM_001197125.2, NM_001197126.2
RefSeq protein: NP_001184051.1, NP_001184052.1, NP_001184053.1, NP_001184054.1, NP_001184055.1

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7. [provided by RefSeq, Sep 2020].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II positive regulation of cytokine production immune system process cytoplasmic pattern recognition receptor signaling pathway regulation of DNA-templated transcription regulation of transcription by RNA polymerase II apoptotic process DNA damage response

Molecular function

transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific

Cellular component

chromatin chromatin nucleus nucleus nucleus nucleus nucleoplasm cytoplasm

Pathways

Toll-like receptor signaling pathway - Homo sapiens (human)NOD-like receptor signaling pathway - Homo sapiens (human)RIG-I-like receptor signaling pathway - Homo sapiens (human)Cytosolic DNA-sensing pathway - Homo sapiens (human)Shigellosis - Homo sapiens (human)Pertussis - Homo sapiens (human)Yersinia infection - Homo sapiens (human)Hepatitis C - Homo sapiens (human)Hepatitis B - Homo sapiens (human)Measles - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

interferon regulatory factor 3

Symbol: IRF3
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:49,659,569-49,665,864
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein IRF3 PDB 1j2f.png

Show 6 more facts

HomoloGene ID: 1208
exact match: identifiers.org/ncbigene/3661
genomic end: 50169132
genomic start: 50162826
cytogenetic location: 19q13.33
Commons category: Interferon regulatory factor 3, IRF-3

Sources (6)

via Wikidata · CC0

~2 min read

Article

5 sections

Contents

Function
Interactions
References
Further reading
External links

Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor.

== Function ==

Available in 6 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 19 Transcription factors