GRB2
Sign in to saveAlso known as ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2, growth factor receptor bound protein 2
Growth factor receptor-bound protein 2, also known as Grb2, is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene.
Gene data
GRB2- Name
- growth factor receptor bound protein 2
- Type
- protein-coding
- Position
- 75,318,076–75,405,709 (−)
- Aliases
- ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2
- Ensembl
- ENSG00000177885
- RefSeq RNA
- NM_002086.5, NM_203506.3
- RefSeq protein
- NP_002077.1, NP_987102.1
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
growth factor receptor bound protein 2
- Symbol
- GRB2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:75,318,072-75,405,720
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Grb2.JPG
Show 6 more facts
- HomoloGene ID
- 1576
- exact match
- identifiers.org/ncbigene/2885
- genomic end
- 73401790
- genomic start
- 73314157
- cytogenetic location
- 17q25.1
- Commons category
- Growth factor receptor-bound protein 2 (GRB2)
via Wikidata · CC0
~4 min read
Article
7 sectionsContents
- Function and expression
- Domains
- Interactions
- See also
- References
- Further reading
- External links
Growth factor receptor-bound protein 2, also known as Grb2, is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene.
The protein encoded by this gene binds receptors such as the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the sem-5 gene of Caenorhabditis elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.